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原著論文

2024年

  • Hinaga S, Kandeel M, Oh-hashi K*. Molecular characterization of the ER stress-inducible factor CRELD2. Cell Biochem Biophys. in press.

  • Sakurai A, Kawaguchi K, Watanabe M, Okajima S, Furukawa S, Koga K, Oh-hashi K, Hirata Y, Furuta K, Takemori H. Melanosomal localization is required for GIF-2115/2250 to inhibit melanogenesis in B16F10 melanoma cells. Int J Cosmet Sci. in press.

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2023年

  • Murase R, Kato G, Oh-hashi K*. Regulation of the ER-resident mannosidase EDEM2 in HEK293 cells. BPB Rep. 2023 6(6):193-199.

  • Kanamori A, Hinaga S, Hirata Y, Amaya F, Oh-hashi K*. Molecular characterization of wild-type and HSAN2B-linked FAM134B. Mol Biol Rep. 2023 50(7):6005-6017.

  • Oh-hashi K*, Nakamura H, Ogawa H, Hirata Y, Sakurai K. Elucidation of OSW-1-Induced Stress Responses in Neuro2a Cells. Int J Mol Sci. 2023 24(6):5787.

  • Uchio-Yamada K, Yasuda K, Oh-hashi K, Manabe N. Abnormal glomerular basement membrane maturation impairs mesangial cell differentiation during murine postnatal nephrogenesis. Am J Physiol Renal Physiol. 2023 324(1):F124-F134.

  • Takahashi M, Hamamoto A, Oh-hashi K, Takemori H, Furuta K, Hirata Y. Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities. ACS Chem Neurosci. 2023 14(10):1826-1833.

  • Kato K, Takahashi M, Oh-hashi K, Ando K, Hirata Y. Quercetin and resveratrol inhibit ferroptosis independently of Nrf2-ARE activation in mouse hippocampal HT22 cells. Food Chem Toxicol. 2023 172:113586.

  • Kawaguchi K, Watanabe M, Furukawa S, Koga K, Kanamori H, Ikemoto MJ, Takashima S, Maeda M, Oh-hashi K, Hirata Y, Furuta K, Takemori H. Intermittent inhibition of FYVE finger-containing phosphoinositide kinase induces melanosome degradation in B16F10 melanoma cells. Mol Biol Rep. 2023 50(7):5917-5930.

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2022年

  • Murase R, Yamamoto A, Hirata Y, Oh-hashi K. Expression analysis and functional characterization of thioredoxin domain-containing protein 11. Mol Biol Rep. 2022 49(11):10541-10556.

  • Hirata Y, Oka K, Yamamoto S, Watanabe H, Oh-hashi K, Hirayama T, Nagasawa H, Takemori H, Furuta K. Haloperidol Prevents Oxytosis/Ferroptosis by Targeting Lysosomal Ferrous Ions in a Manner Independent of Dopamine D2 and Sigma-1 Receptors. ACS Chem Neurosci. 2022 13(18):2719-2727.

  • Takashima S, Fujita H, Toyoshi K, Ohba A, Hirata Y, Shimozawa N, Oh-hashi K*. Hypomorphic mutation of PEX3 with peroxisomal mosaicism reveals the oscillating nature of peroxisome biogenesis coupled with differential metabolic activities. Mol Genet Metab. 2022 137(1-2):68-80.

  • Hirata Y, Okazaki R, Sato M, Oh-hashi K, Takemori H, Furuta K. Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and ,-dimethylaniline derivatives on rotenone-induced oxidative stress. Eur J Pharmacol. 2022 928:175119.

  • Hasegawa Y, Motoyama M, Hamamoto A, Kimura S, Kamatari YO, Kamishina H, Oh-hashi K, Furuta K, Hirata Y. Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones. ACS Chem Neurosci. 2022 13(7):1055-1064.

  • Burayk S, Oh-hashi K, Kandeel M. Drug Discovery of New Anti-Inflammatory Compounds by Targeting Cyclooxygenases. Pharmaceuticals (Basel). 2022 15(3):282.

  • Takemori H, Koga K, Kawaguchi K, Furukawa S, Ito S, Imaishi J, Watanabe M, Maeda M, Mizoguchi M, Oh-hashi K, Hirata Y, Furuta K. Visualization of mitophagy using LysoKK, a 7-nitro-2,1,3-benzoxadiazole-(arylpropyl)benzylamine derivative. Mitochondrion. 2022 62:176-180.

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2021年

  • Hirata Y, Motoyama M, Kimura S, Takashima M, Ikawa T, Oh-hashi K, Kamatari YO. Artepillin C, a major component of Brazilian green propolis, inhibits endoplasmic reticulum stress and protein aggregation. Eur J Pharmacol. 2021 912:174572.

  • Hirata Y, Tsunekawa Y, Takahashi M, Oh-hashi K, Kawaguchi K, Hayazaki M, Watanabe M, Koga KI, Hattori Y, Takemori H, Furuta K. Identification of novel neuroprotective,-dimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes. Free Radic Biol Med. 2021 174:225-235.

  • Oh-hashi K*, Hasegawa T, Mizutani Y, Takahashi K, Hirata Y. Elucidation of brefeldin A-induced ER and Golgi stress responses in Neuro2a cells. Mol Cell Biochem. 2021 476(10):3869-3877. 

  • Kandeel M, Abdelrahman AHM, Oh-hashi K, Ibrahim A, Venugopala KN, Morsy MA, Ibrahim MAA. Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease. J Biomol Struct Dyn. 2021 39(14):5129-5136.

  • Maeda M, Suzuki M, Takashima S, Sasaki T, Oh-hashi K, Takemori H. The new live imagers MitoMM1/2 for mitochondrial visualization. Biochem Biophys Res Commun. 2021 562:50-54.

  • Oh-hashi K*, Hasegawa T, Naruse Y, Hirata Y. Molecular characterization of mouse CREB3 regulatory factor in Neuro2a cells. Mol Biol Rep. 2021 48(7):5411-5420.

  • Kandeel M, Yamamoto M, Park BK, Al-Taher A, Watanabe A, Gohda J, Kawaguchi Y, Oh-hashi K, Kwon HJ, Inoue JI. Discovery of New Potent anti-MERS CoV Fusion Inhibitors. Front Pharmacol. 2021 12:685161.

  • Ikawa T, Sato M, Oh-hashi K, Furuta K, Hirata Y. Oxindole-curcumin hybrid compound enhances the transcription of γ-glutamylcysteine ligase. Eur J Pharmacol. 2021 896:173898.

  • Oh-hashi K*, Yamamoto A, Murase R, Hirata Y. Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells. Int J Mol Sci. 2021 22(5):2767. 

  • Oh-hashi K*, Kohno H, Hirata Y. Transcriptional regulation of the ER stress-inducible gene Sec16B in Neuro2a cells. Mol Cell Biochem. 2021 476(1):35-44.

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2020年

  • Nomura Y, Sylvester CF, Nguyen LO, Kandeel M, Hirata Y, Mungrue IN, Oh-hashi K*. Characterization of the 5'-flanking region of the human and mouse CHAC1 genes. Biochem Biophys Rep. 2020 24:100834.

  • Oh-hashi K*, Kohno H, Kandeel M, Hirata Y. Characterization of IRE1α in Neuro2a cells by pharmacological and CRISPR/Cas9 approaches. Mol Cell Biochem. 2020 465(1-2):53-64.

  • Kandeel M, Yamamoto M, Al-Taher A, Watanabe A, Oh-hashi K, Park BK, Kwon HJ, Inoue JI, Al-Nazawi M. Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers. Biomol Ther (Seoul). 2020 28(4):311-319.

  • Yagyu K, Hasegawa Y, Sato M, Oh-hashi K, Hirata Y. Activation of protein kinase R in the manganese-induced apoptosis of PC12 cells. Toxicology. 2020 442:152526.

  • Nagase H, Katagiri Y, Oh-hashi K, Geller HM, Hirata Y. Reduced Sulfation Enhanced Oxytosis and Ferroptosis in Mouse Hippocampal HT22 Cells. Biomolecules. 2020 10(1):92.

  • Hirata Y, Ito Y, Takashima M, Yagyu K, Oh-hashi K, Suzuki H, Ono K, Furuta K, Sawada M. Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection. ACS Chem Neurosci. 2020 11(1):76-85.

  • Oh-hashi K*, Hirata Y. Elucidation of the Molecular Characteristics of Wild-Type and ALS-Linked Mutant SOD1 Using the NanoLuc Complementation Reporter System. Appl Biochem Biotechnol. 2020 190(2):674-685.

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2019年

  • Oh-hashi K*, Takahashi K, Hirata Y. Regulation of the ER-bound transcription factor Luman/CREB3 in HEK293 cells. FEBS Lett. 2019 593(19):2771-2778.

  • Oh-hashi K*, Matsumoto S, Sakai T, Hirata Y, Okuda K, Nagasawa H. Effects of 2-(2-Chlorophenyl)ethylbiguanide on ERAD Component Expression in HT-29 Cells Under a Serum- and Glucose-Deprived Condition. Appl Biochem Biotechnol. 2019 188(4):1009-1021.

  • Kandeel M, Al-Taher A, Al-Nazawi M, Oh-hashi K. Substructural dynamics of the phase-I drug metabolizing enzyme, carbonyl reductase 1, in response to various substrate and inhibitor configurations. Trop J Pharm Res. 2019 18:1635-1641.

  • Hirata Y, Iwasaki T, Makimura Y, Okajima S, Oh-hashi K, Takemori H. Inhibition of double-stranded RNA-dependent protein kinase prevents oxytosis and ferroptosis in mouse hippocampal HT22 cells. Toxicology. 2019 418:1-10.

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2018年

  • Oh-hashi K*, Fujimura K, Norisada J, Hirata Y. Expression analysis and functional characterization of the mouse cysteine-rich with EGF-like domains 2. Sci Rep. 2018 8(1):12236.

  • Oh-hashi K*, Matsumoto S, Sakai T, Nomura Y, Okuda K, Nagasawa H, Hirata Y. Elucidating the rapid action of 2-(2-chlorophenyl)ethylbiguanide on HT-29 cells under a serum- and glucose-deprived condition. Cell Biol Toxicol. 2018 34(4):279-290.

  • Oh-hashi K*, Soga A, Naruse Y, Takahashi K, Kiuchi K, Hirata Y. Elucidating post-translational regulation of mouse CREB3 in Neuro2a cells. Mol Cell Biochem. 2018 448(1-2):287-297.

  • Oh-hashi K*, Sugiura N, Amaya F, Isobe KI, Hirata Y. Functional validation of ATF4 and GADD34 in Neuro2a cells by CRISPR/Cas9-mediated genome editing. Mol Cell Biochem. 2018 440(1-2):65-75.

  • Norisada J, Fujimura K, Amaya F, Kohno H, Hirata Y, Oh-hashi K*. Application of NanoBiT for Monitoring Dimerization of the Null Hong Kong Variant of α-1-Antitrypsin, NHK, in Living Cells. Mol Biotechnol. 2018 60(8):539-549.

  • Yamaguchi Y, Oh-hashi K, Matsuoka Y, Takemura H, Yamakita S, Matsuda M, Sawa T, Amaya F. Endoplasmic Reticulum Stress in the Dorsal Root Ganglion Contributes to the Development of Pain Hypersensitivity after Nerve Injury. Neuroscience. 2018 394:288-299.

  • Shinjo T, Tanaka T, Okuda H, Kawaguchi AT, Oh-hashi K, Terada Y, Isonishi A, Morita-Takemura S, Tatsumi K, Kawaguchi M, Wanaka A. Propofol induces nuclear localization of Nrf2 under conditions of oxidative stress in cardiac H9c2 cells. PLoS One. 2018 13(4):e0196191.

  • Hirata Y, Yamada C, Ito Y, Yamamoto S, Nagase H, Oh-hashi K, Kiuchi K, Suzuki H, Sawada M, Furuta K. Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells. Neuropharmacology. 2018 135:242-252.

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2017年

  • Oh-hashi K*, Furuta E, Fujimura K, Hirata Y. Application of a novel HiBiT peptide tag for monitoring ATF4 protein expression in Neuro2a cells. Biochem Biophys Rep. 2017 12:40-45.

  • Matsuda M, , Yokota I, Sawa T, Amaya F. Acquired Exchange Protein Directly Activated by Cyclic Adenosine Monophosphate Activity Induced by p38 Mitogen-activated Protein Kinase in Primary Afferent Neurons Contributes to Sustaining Postincisional Nociception. Anesthesiology. 2017 126(1):150-162.

  • Shibata S, Furuta K, Oh-hashi K, Ueda H, Kiuchi K, Hirata Y. Prevention of oxytosis-induced c-Raf down-regulation by (arylthio)cyclopentenone prostaglandins is neuroprotective. Toxicology. 2017 390:83-87.

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2016年

  • Oh-hashi K*, Furuta E, Norisada J, Amaya F, Hirata Y, Kiuchi K. Application of NanoLuc to monitor the intrinsic promoter activity of GRP78 using the CRISPR/Cas9 system. Genes Cells. 2016 21(10):1137-1143.

  • Oh-hashi K*, Hirata Y, Kiuchi K. SOD1 dimerization monitoring using a novel split NanoLuc, NanoBit. Cell Biochem Funct. 2016 34(7):497-504.

  • Oh-hashi K*, Irie N, Sakai T, Okuda K, Nagasawa H, Hirata Y, Kiuchi K. Elucidation of a novel phenformin derivative on glucose-deprived stress responses in HT-29 cells. Mol Cell Biochem. 2016 419(1-2):29-40.

  • Nomura Y, Hirata Y, Kiuchi K, Oh-hashi K*. Translational and post-translational regulation of mouse cation transport regulator homolog 1. Sci Rep. 2016 6:28016.

  • Norisada J, Hirata Y, Amaya F, Kiuchi K, Oh-hashi K*. A Comparative Analysis of the Molecular Features of MANF and CDNF. PLoS One. 2016 11(1):e0146923.

  • Shimosato G, Oh-hashi K*, Yamaguchi Y, Amaya F. Distinctive expression of TMEM132A and its regulation after the nerve injury in the DRG. Biomed Res Clin Practice. 2016 1(3):109-111.

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2015年

  • Hikiji T, Norisada J, Hirata Y, Okuda K, Nagasawa H, Ishigaki S, Sobue G, Kiuchi K, Oh-hashi K*. A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors. Biochem Biophys Res Commun. 2015 463(4):881-887.

  • Oh-hashi K*, Sone A, Hikiji T, Hirata Y, Vitiello M, Fedele M, Ishigaki S, Sobue G, Kiuchi K. Transcriptional and post-transcriptional regulation of transmembrane protein 132A. Mol Cell Biochem. 2015 405(1-2):291-299.

  • Oh-hashi K*, Norisada J, Hirata Y, Kiuchi K. Characterization of the Role of MANF in Regulating the Secretion of CRELD2. Biol Pharm Bull. 2015 38(5):722-731.

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2014年

  • Oh-hashi K*, Kanamori Y, Hirata Y, Kiuchi K. Characterization of V-ATPase inhibitor-induced secretion of cysteine-rich with EGF-like domains 2. Cell Biol Toxicol. 2014 30(3):127-136.

  • Norisada J, Hirata Y, Amaya F, Kiuchi K, Oh-hashi K*. A sensitive assay for the biosynthesis and secretion of MANF using NanoLuc activity. Biochem Biophys Res Commun. 2014 449(4):483-489.

  • Kandeel M, Noguchi Y, Oh-hashi K, Kim H, Kitade Y. Molecular dynamics and energetic perceptions of substrate recognition by thymidylate kinase. J Therm Anal Calorim. 2014 115:2089-2097.

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2013年

  • Oh-hashi K*, Nomura Y, Shimada K, Koga H, Hirata Y, Kiuchi K. Transcriptional and post-translational regulation of mouse cation transport regulator homolog 1. Mol Cell Biochem. 2013 380(1-2):97-106.

  • Oh-hashi K*, Hirata Y, Kiuchi K. Transcriptional regulation of mouse mesencephalic astrocyte-derived neurotrophic factor in Neuro2a cells. Cell Mol Biol Lett. 2013 18(3):398-415.

  • Oh-hashi K*, Tejima T, Hirata Y, Kiuchi K. Characterization of the 5'-flanking region of the mouse asparagine-linked glycosylation 12 homolog gene. Cell Mol Biol Lett. 2013 18(3):315-327.

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2012年

  • Oh-hashi K*, Koga H, Nagase T, Hirata Y, Kiuchi K. Characterization of the expression and cell-surface localization of transmembrane protein 132A. Mol Cell Biochem. 2012 370(1-2):23-33.

  • Oh-hashi K, Hirata Y, Kiuchi K. Characterization of 3'-untranslated region of the mouse GDNF gene. BMC Mol Biol. 2012 13:2.

  • Oh-hashi K*, Tanaka K, Koga H, Hirata Y, Kiuchi K. Intracellular trafficking and secretion of mouse mesencephalic astrocyte-derived neurotrophic factor. Mol Cell Biochem. 2012 363(1-2):35-41.

  • Tsuji F, Oh-hashi K, Kiuchi K. Differential effects of Akt pathway inhibitors on IL-1β-induced protein phosphorylation in human fibroblast-like synoviocytes. J Recept Signal Transduct Res. 2012 32(1):22-28.

  • Uchida A, Oh-hashi K, Kiuchi K, Hirata Y. Manganese regulates caspase-3 gene promoter activity by inducing Sp1 phosphorylation in PC12 cells. Toxicology. 2012 302(2-3):292-298.

  • Hirata Y, Furuta K, Suzuki M, Oh-hashi K, Ueno Y, Kiuchi K. Neuroprotective cyclopentenone prostaglandins up-regulate neurotrophic factors in C6 glioma cells. Brain Res. 2012 1482:91-100.

  • Osman W, Endo S, Oh-hashi K, Kitamura Y, Kitade Y. Molecular characterization and mutational analysis of recombinant diadenosine 5',5″-P¹,P⁴-tetraphosphate hydrolase from Plasmodium falciparum. Biol Pharm Bull. 2012 35(7):1191-1196.

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2011年

  • Oh-hashi K*, Kunieda R, Hirata Y, Kiuchi K. Biosynthesis and secretion of mouse cysteine-rich with EGF-like domains 2. FEBS Lett. 2011 585(15):2481-2487.

  • Hirata Y, Yamamoto H, Atta MS, Mahmoud S, Oh-hashi K, Kiuchi K. Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor. J Neurochem. 2011 119(4):839-847.

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2010年

  • Oh-hashi K*, Koga H, Ikeda S, Shimada K, Hirata Y, Kiuchi K. Role of an ER stress response element in regulating the bidirectional promoter of the mouse CRELD2 - ALG12 gene pair. BMC Genomics. 2010 11:664.

  • Oh-hashi K*, Imai K, Koga H, Hirata Y, Kiuchi K. Knockdown of transmembrane protein 132A by RNA interference facilitates serum starvation-induced cell death in Neuro2a cells. Mol Cell Biochem. 2010 342(1-2):117-123.

  • Hashimoto S, Amaya F, Oh-hashi K, Kiuchi K, Hashimoto S. Expression of neutral endopeptidase activity during clinical and experimental acute lung injury. Respir Res. 2010 11(1):164.

  • Hirata Y, Shimokawa N, Oh-hashi K, Yu ZX, Kiuchi K. Acidification of the Golgi apparatus is indispensable for maturation but not for cell surface delivery of Ret. J Neurochem. 2010 115(3):606-613.

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2009年

  • Oh-hashi K*, Koga H, Ikeda S, Shimada K, Hirata Y, Kiuchi K. CRELD2 is a novel endoplasmic reticulum stress-inducible gene. Biochem Biophys Res Commun. 2009 387(3):504-510.

  • Oh-hashi K, Ito M, Tanaka T, Hirata Y, Kiuchi K. Biosynthesis, processing, and secretion of glial cell line-derived neurotrophic factor in astroglial cells. Mol Cell Biochem. 2009 323(1-2):1-7.

  • Shibata S, Furuta K, Maeda M, Suzuki M, Oh-hashi K, Kiuchi K, Hirata Y. (Arylthio)cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPARg-dependent pathway. Brain Res. 2009 1296:196-202.

  • Shibata S, Maeda M, Furuta K, Suzuki M, Oh-hashi K, Kiuchi K, Hirata Y. Neuroprotective effects of (arylthio)cyclopentenone derivatives on manganese-induced apoptosis in PC12 cells. Brain Res. 2009 1294:218-225.

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2008年

  • Oh-hashi K, Ohkubo K, Shizu K, Fukuda H, Hirata Y, Kiuchi K. Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2. Mol Cell Biochem. 2008 313(1-2):103-111.

  • Tanaka T, Oh-hashi K, Ito M, Shitara H, Hirata Y, Kiuchi K. Identification of a novel GDNF mRNA induced by LPS in immune cell lines. Neurosci Res. 2008 61(1):11-17.

  • Tanaka T, Oh-hashi K, Shitara H, Hirata Y, Kiuchi K. NF-kB independent signaling pathway is responsible for LPS-induced GDNF gene expression in primary rat glial cultures. Neurosci Lett. 2008 431(3):262-267.

  • Tsuruta T, Oh-hashi K, Kiuchi K, Hirata Y. Degradation of caspase-activated DNase by the ubiquitin-proteasome system. Biochim Biophys Acta. 2008 1780(5):793-799.

  • Hirata Y, Suzuno H, Tsuruta T, Oh-hashi K, Kiuchi K. The role of dopamine transporter in selective toxicity of manganese and rotenone. Toxicology. 2008 244(2-3):249-256.

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2007年

  • Tsuruta T, Oh-hashi K, Ueno Y, Kitade Y, Kiuchi K, Hirata Y. RNAi knockdown of caspase-activated DNase inhibits rotenone-induced DNA fragmentation in HeLa cells. Neurochem Int. 2007 50(4):601-606.

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2006年

  • Oh-hashi K, Hirata Y, Koga H, Kiuchi K. GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells. FEBS Lett. 2006 580(16):3943-3947.

  • Oh-hashi K, Kaneyama M, Hirata Y, Kiuchi K. ER calcium discharge stimulates GDNF gene expression through MAPK-dependent and -independent pathways in rat C6 glioblastoma cells. Neurosci Lett. 2006 405(1-2):100-105.

  • Hara H, Oh-hashi K, Yoneda S, Shimazawa M, Inatani M, Tanihara H, Kiuchi K. Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy. Mol Vis. 2006 12:977-982.

  • Yu H, Oh-hashi K, Tanaka T, Sai A, Inoue M, Hirata Y, Kiuchi K. Rehmannia glutinosa induces glial cell line-derived neurotrophic factor gene expression in astroglial cells via cPKC and ERK1/2 pathways independently. Pharmacol Res. 2006 54(1):39-45.

  • Ito Y, Oh-hashi K, Kiuchi K, Hirata Y. p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells. Brain Res. 2006 1099(1):1-7.

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2005年

  • Oh-hashi K, Nagai T, Tanaka T, Yu H, Hirata Y, Kiuchi K. Determination of hypoxic effect on neprilysin activity in human neuroblastoma SH-SY5Y cells using a novel HPLC method. Biochem Biophys Res Commun. 2005 334(2):380-385.

 

2004年以前は、ResearchmapまたはPubmedにてご確認下さい。

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